杨智晖　　潘　洁　　李　林　　刘　青　　张　倩　　孙建璞　　宋　霄　　赵勇军

河北省老年病医院普通内科，河北石家庄　050011

替普瑞酮对幽门螺旋杆菌感染相关老年消化性溃疡的临床疗效

杨智晖潘洁李林刘青张倩孙建璞宋霄赵勇军

河北省老年病医院普通内科，河北石家庄050011

目的 探讨替普瑞酮对幽门螺旋杆菌（Hp）感染相关老年消化性溃疡的临床疗效。方法 选取2013年6月～2014年12月来河北省老年病医院就诊治疗的72例Hp感染相关性老年消化性溃疡患者作为研究对象，将其随机分为干预组和对照组。干预组给予替普瑞酮联合雷贝拉唑三联疗法，对照组给予雷贝拉唑三联疗法加用安慰剂。观察两组临床疗效、Hp根除及不良反应发生情况。结果 干预组0～4、5～24周时临床治疗总有效率分别为97.30%（36/37）、85.71%（30/35），明显高于对照组 ［78.13%（25/32）、60.00%（18/30）］，差异有统计学意义 （P＜0.05）；干预组0～4、5～24周时胃镜下总有效率分别为83.78%（31/37）、88.57%（31/35），明显高于对照组［50.00%（16/32）、60.00%（18/30）］，差异有统计学意义 （P＜0.05）；干预组0～4、5～24周时Hp清除率分别为97.30%（36/ 37）、77.14%（27/35），明显高于对照组［78.13%（25/32）、50.00%（15/30）］，差异有统计学意义（P＜0.05）。干预组和对照组患者用药0～4周不良反应发生率分别为10.81%（4/37）、9.38%（3/32），两组比较差异无统计学意义 （P＞0.05）。结论 替普瑞酮联合雷贝拉唑三联疗法可明显提高Hp相关老年消化性溃疡的临床疗效，且安全性高。

替普瑞酮；老年；消化性溃疡；幽门螺旋杆菌；疗效

［Abstract］Objective To evaluate the clinical efficacy of Teprenone for helicobacter pylori（Hp）associated elderly peptic ulcer.M ethods Seventy-two cases of patientswith Hp associated elderly peptic ulcer treated in Hebei Province Geriatric Hospital from June 2013 to December 2014 were selected as research objects，and they were randomly divided into intervention group and control group.The intervention group was given Teprenone combined with Rabeprazolebase triple therapy.Control group was given Rabeprazole-base triple therapy combined with placebo.The clinical effect，Hp eradicating and adverse reactions between the two groups were observed.Results The clinical total effective rate at 0-4，5-24 weeks in the intervention group was 97.30%（36/37），85.71%（30/35）respectively，which were higher than those of control group［78.13%（25/32），60.00%（18/30）］，the differences were statistically significant（P＜0.05）；the total effective rate under the gastroscope at 0-4，5-24 weeks in the intervention group was 83.78%（31/37），88.57%（31/35）respectively，which were higher than those of control group［50.00%（16/32），60.00%（18/30）］，the differences were statistically significant（P＜0.05）；the eradicating rate of Hp at 0-4，5-24 weeks in the intervention group was 97.30%（36/37），77.14%（27/35），which were higher than those of control group［78.13%（25/32），50.00%（15/30）］，the differenceswere statistically significant（P＜0.05）.The incidence of adverse reactions after drug use for 0-4 weeks in the intervention group and control group was 10.81%（4/37），9.38%（3/32）respectively，there was no statistically significant difference（P＞0.05）.Conclusion Teprenone combined with Rabeprazole-base triple therapy can obviously improve the clinical effect of Hp associated peptic ulcer in the elderly，with high safety.

［Key words］Teprenone；Elderly；Peptic ulcer；Helicobacter pylori；Efficacy

近年来，消化性溃疡患病率在全世界范围内呈下降趋势，相反老年患者住院和死亡率依然居高不下［1］。老年消化性溃疡是指由于幽门螺旋杆菌（helicobacter pylori，Hp）、服用非甾体类抗炎药物、抽烟、饮酒等引起60岁以上老年人患有的胃溃疡，属于一种特殊类型的消化性溃疡［2］。……