杨正东

【摘要】 目的：研究显微镜下经鼻蝶窦入路行垂体瘤切除手术疗效及安全性。方法：选取笔者所在医院收治的44例垂体瘤患者，对其进行显微镜下经鼻蝶窦入路肿瘤切除手术。观察治疗效果、并发症以及相关激素水平变化。结果：显微镜下手术治疗泌乳素腺瘤有效率为94.44%；治疗生长激素腺瘤有效率为92.86%；治疗皮质激素腺瘤的有效率为85.71%；治疗无功能腺瘤有效率为80.00%。手术后泌乳素腺瘤患者的泌乳素水平显著降低，生长激素腺瘤患者的生长激素水平显著降低。44例垂体瘤患者手术后有3例（6.82%）并发症。结论：对垂体瘤患者进行显微镜下经鼻蝶窦入路的垂体瘤切除手术可以有效治疗患者病症，改善患者激素水平，减少患者术后并发症。

【关键词】 显微镜； 鼻蝶窦； 垂体瘤切除术

中图分类号 R584 文献标识码 B 文章编号 1674-6805（2016）6-0016-02

Efficacy and Safety of Pituitary Tumor Resection of Nasal Transsphenoidal Approach with Microscope/YANG Zheng-dong.//Chinese and Foreign Medical Research，2016，14（6）：16-17

【Abstract】 Objective：To research under the microscope by endonasal transsphenoidal approach for pituitary adenoma resection surgery efficacy and safety.Method：The hospital of 44 cases of pituitary tumor were selected and treated with the microscope via endonasal transsphenoidal approach tumor resection.To observe the therapeutic effect，complications and related changes in hormone levels.Result：Under the microscope surgical treatment of lactation prolactinomas effective rate was 94.44%；growth hormone adenoma treatment effective rate was 92.86%；treatment of cortical hormone adenoma efficiency was 85.71%；treatment of non functioning adenomas effective rate was 80.00%.Surgery after prolactin adenomas in patients with prolactin level decreased significantly.Growth hormone secreting pituitary adenomas in patients with growth hormone levels decreased significantly.The complications were 3 cases（6.82%） after pituitary tumor resection in 44 cases.Conclusion：In patients with pituitary adenoma which are performed under microscope via transsphenoidal sinus approach road of pituitary tumor resection can be effective in the treatment of patients with symptoms，reduce the postoperative complications，improve the hormone levels of patients.

【Key words】 Microscope； Nasal sinus； Pituitary tumor resection

First-authors address：Dehong Peoples Hospital，Luxi 678400，China

doi：10.14033/j.cnki.cfmr.2016.6.008

作為神经外科比较常见的一种肿瘤，垂体瘤的发生率比较高（5%左右），引起了医生和社会各界的广泛关注。手术切除是目前治疗垂体瘤的常见方法，科学的手术切除可以保证最大限度的切除肿瘤组织而尽可能保留垂体，患者亦可以在较短时间内恢复[1]。传统的开颅手术给患者带来的创伤大，手术不良反应发生率比较高，因而逐渐被淘汰，取而代之的是微创疗法，使用显微镜进行垂体瘤手术治疗已经成为现在常用的手术方法[2-3]。笔者研究了44例垂体瘤患者在显微镜下经鼻蝶窦入路进行垂体瘤切除手术的实际疗效以及其安全性，现将结果阐述如下。……