靳宏光李　俊李延吉郭家娟△

（1．长春中医药大学附属医院，吉林　长春130021；2.长春中医药大学，吉林　长春130017）

痰瘀同治法对不稳定型心绞痛疗效及血FINS、hs-CRP影响的临床观察*

靳宏光1李俊2李延吉2郭家娟1△

（1．长春中医药大学附属医院，吉林长春130021；2.长春中医药大学，吉林长春130017）

目的探讨痰瘀同治法对冠心病不稳定型心绞痛的临床疗效。方法72例患者随机分为治疗组和对照组各36例。对照组给予西医规范化治疗，治疗组在对照组基础上加服具有痰瘀同治功用的参红化浊通络方，疗程为2周。观察两组试验前后的心绞痛计分、西雅图心绞痛调查量表（SAQ）积分、血胰岛素（FINS）、超敏C反应蛋白（hs-CRP）变化，并进行统计分析。结果治疗后两组的心绞痛计分与治疗前比较均明显下降（均P＜0.01），且治疗组优于对照组（P＜0.05）。两组治疗前SAQ中5个维度积分组间比较差别不大（均P＞0.05）。治疗后SAQ中5个维度积分较治疗前均明显增加（均P＜0.05），且治疗组在活动受限程度、心绞痛发作情况及治疗满意度方面均优于对照组（均P＜0.05）。治疗后，两组FINS、hs-CRP水平与治疗前比较均有不同程度改善（P＜0.05或P＜0.01），且治疗组均优于对照组（均P＜0.05）。两组治疗过程中安全性指标监测均未见异常，亦未见明显不良反应。结论痰瘀同治法对冠心病不稳定型心绞痛具有良好疗效。

不稳定型心绞痛痰瘀同治血胰岛素超敏C反应蛋白

【Abstract】Objective：To evaluate the clinical efficacy of phlegm and blood stasis in patients with unstable angina pectoris.Methods：72 patients were randomly divided into the treatment group and the control group，36 cases in each.The control group was given western medicine standardized treatment，while the treatment group was given Shenhong Huazhuo Tongluo Decoction.The treatment lasted for 2 weeks.The angina scores，Seattle Angina Questionnaire（SAQ）scores，blood insulin（FINS），and high sensitive Creactive protein（hs-CRP）changes of two groups were observed before and after treatment，and then a statistical analysis was made.Results：After treatment，the scores of angina pectoris in the two groups decreased significantly compared with those before treatment（P＜0.01）；and the treatment group was better than the control group（P＜0.05）.Before treatment，there was little difference between 5 dimensional integration in the SAQ（P＞0.05）.After treatment，5 dimension scores were significantly increased compared with those before treatment（P＜0.05）.And the treatment group was better than the control group in the degree of activity limitation，as well as angina attack and treatment satisfaction（P＜0.05）.Before treatment，there was little difference between the two groups in hs-CRP and FINS levels（P＞0.05）.After treatment，there were varying degrees of improvement in the levels of hs-CRP and FINS in the two groups compared with those before treatment（P＜0.05 or P＜0.01），and the treatment group were better than the control group（P＜0.05）.In the treatment process，there were no abnormal safety indicators and no obvious adverse reactions found in either group.Conclusion：Phlegm and blood stasis method has a good curative effect on unstable angina pectoris.【Key words】Unstable angina pectoris；Phlegm and blood stasis；Blood insulin；High sensitive C reactive protein（hs-CRP）

不稳定型心绞痛（UA）是介于稳定型心绞痛和急性心肌梗死之间的中间临床综合征，以不稳定动脉粥样硬化斑块为主要特征［1-2］，易形成冠状动脉血栓，进而引起心肌血流灌注急剧减少，进展为心肌梗死几率较高，严重威胁生命安全［3］。……