秦文婧　张双林河南大学第一附属医院呼吸内科，河南开封　475000

雌激素受体、孕激素受体及原癌基因Her-2在肺腺癌中的表达

秦文婧张双林
河南大学第一附属医院呼吸内科，河南开封475000

目的 探讨雌激素受体（ER）、孕激素受体（PR）及原癌基因Her-2（C-erbB-2）在肺腺癌发生发展过程中的作用。方法 选择2013年3月～2015年2月在我院手术治疗的肺腺癌患者组织切块60例为研究对象。分析不同性别、年龄、分化程度、临床分期患者肺腺癌中ER、PR及C-erbB-2的表达，分析肺腺癌患者组织中C-erbB-2的表达与ER、PR表达的相关性，分析骨转移患者与无骨转移患者肺腺癌组织中ER、PR、C-erbB-2的表达。结果 60例患者，14例ER阳性表达，占23.3%，13例PR阳性，占21.7%，6例C-erbB-2阳性，占10.0%。分化程度越低的患者ER阳性率及C-erbB-2阳性率越高（P＜0.05）。不同性别、临床分期肺腺癌患者组织中ER、PR及C-erbB-2表达无差异（P＞0.05）。相关性分析：C-erbB-2与ER表达呈显著正相关的关系（r=0.461），C-erbB-2表达与PR呈正相关（r=0.326）；C-erbB-2与ER及PR均为阳性呈显著正相关的关系（r=0.329），ER与PR表达无相关性（r=0.081）。骨转移患者与无骨转移患者肺腺癌组织中ER、PR及C-erbB-2表达无差异（P＞0.05）。结论 肺腺癌中均可表达一定程度的雌激素受体、孕激素受体及原癌基因Her-2水平。

雌激素受体；孕激素受体；原癌基因Her-2；肺腺癌

[Abstract]Objective To discuss expression of ER，PR and C-erbB-2 with lung adenocarcinoma.Methods Diced tissues of 60 cases with lung adenocarcinoma from Mar 2013 to Feb 2015 were selected.ER，PR and C-erbB-2 levels in patients of different sex，age，degree of differentiation，clinical stage were analyzed.Association of C-erbB-2 expression with ER and PR was analyzed.ER，PR and C-erbB-2 levels in patients with bone metastases and non bone metastasis were analyzed.Results In 60 cases，ER positive expression in 14 cases，accounted for 23.3%，13 cases of PR positive，accounted for 21.7%，and 6 cases of C-erbB-2 positive，accounted for 10%.ER and C-erbB-2 positive rates in patients with the lower the degree of differentiation were higher（P＜0.05）.ER，PR and C-erbB-2 positive rates in patients with different sex，there was no significant difference in the clinical stage（P＞0.05）.C-erbB-2 and ER expression was significantly positive correlation relationship（r=0.461），C-erbB-2 expression and PR were positively correlated（r=0.326）;C-erbB-2，ER and PR were positive significant positive correlation relationship（r=0.329），ER and PR expression no correlation（r=0.081）.ER，PR and C-erbB-2 expressions showed no significant difference in patients with bone metastases and non bone metastasis（P＞0.05）.Conclusion ER，PR and C-erbB-2 express in lung adenocarcinoma.

[Key words]ER;PR;C-erbB-2;Lung adenocarcinoma

近年来内分泌治疗肿瘤取得了较大的进展，相关研究也越来越多，尤其是前列腺癌、乳腺癌等内分泌相关癌症。有学者报道肺癌组织中存在雌激素受体（estrogen receptor，ER）、孕激素受体（progesterone receptor，PR），随后这种结论由多种方法证实[1]。肺腺癌容易发生骨转移，而骨骼中雌激素受体高表达，且两者之间可能存在一定的相关性。孕激素是雌激素的调控基因产物，反映了雌激素的功能及活性，而原癌基因Her-2（Proto-oncogene HER-2，C-erbB-2）是与雌激素受体表达相关受体，与肺癌的预后相关[2，3]。……