刘小伟，殷国海，南征（.长春中医药大学研究生学院，吉林长春3007；.重庆市中医院4000；3.长春中医药大学附属医院，吉林长春300）

·论著·

杞精消肾安汤治疗消渴肾病（糖尿病肾病）临床疗效*

刘小伟1，殷国海2，南征3△
（1.长春中医药大学研究生学院，吉林长春130017；2.重庆市中医院400011；3.长春中医药大学附属医院，吉林长春130021）

目的观察杞精消肾安汤在治疗消渴肾病（糖尿病肾病）肝肾阴虚兼淤毒证中的临床疗效。方法选取2014年3月至2015年7月长春中医药大学附属医院门诊及内分泌疗区收治的60例消渴肾病患者，采用随机对照法将其分为治疗组和对照组，各30例。治疗组采用杞精消肾安汤加减治疗，对照组采用六味地黄丸治疗。均以3个月（12周）为1个疗程，根据病情需要可连续治疗2～3个疗程。结果治疗组总有效率为86.67%（26/30），对照组为56.67%（17/30），二者比较，差异有统计学意义（P＜0.01）。结论杞精消肾安汤在治疗消渴肾病中的临床疗效显著，值得进一步开发和研究。

糖尿病肾病；糖尿病；消渴；肾病；蛋白尿；血糖

【Abstract】Objective To observe the clinical effect of Qijing Xiaoshen′an Decoction in treating diabetic nephropathy with liver-kidney Yin deficiency complicating siltation-toxicity syndrome.M ethods Sixty cases of diabetic nephropathy in the outpatient department and endocrinology department of Affiliated Hospital of Changchun University of Chinese Medicine from March 2014 to July 2015 were selected and divided into the treatment group and controlgroup，30 cases in each group.The treatment group received the therapy of modified Qijing Xiaoshen′an Decoction，while the controlgroup adopted the therapy of Liuwei Dihuang Pills，with 3 months（12weeks）asa treat ment course.The continuous 2-3 treat ment courses could be lasted according to the disease condition.Results The totaleffective rate in the treatment group was 86.67%（26/30），which in the control group was 56.67%（17/30），therewas statistically significant difference between 2 groups（P＜0.01）.Conclusion Qijing Xiaoshen′an Decoction in treating diabetic nephropathy has significantly clinical effectand isworthy of further research and development.

【Key words】Diabetic nephropathies；Diabetesmellitus；Excess eating drinking urine；Nephrosis；Proteinuria；Blood glucose

消渴肾病（糖尿病肾病）是糖尿病微血管并发症之一，又称糖尿病性肾小球硬化症，为糖尿病特有的并发症，是一种复合病因的综合疾病，其患病率为20%～40%。消渴肾病肝肾阴虚兼淤毒证病情复杂，这种症型临床上比较普遍，许多医学家都以消渴肾病肝肾阴虚兼淤毒证为其发病的诸多病因之一，治疗上应及早入手，目前西医对该病有效的治疗方法较少。杞精消肾安汤是长春中医药大学南征教授工作室多年来治疗消渴肾病肝肾阴虚兼淤毒证的有效方剂，取得了较好的临床疗效。……