田岐娟黑龙江省大庆市萨尔图区疾病预防控制中心检验科，黑龙江大庆　163000

糖尿病肾病患者糖化血红蛋白、尿微量蛋白检验分析

田岐娟
黑龙江省大庆市萨尔图区疾病预防控制中心检验科，黑龙江大庆163000

目的分析应用糖化血红蛋白（HbA1c）与尿微量蛋白（U-mAlb）作为糖尿病肾病诊断指标的临床效果。方法选择2014年8月—2015年9月该院收治的35例糖尿病肾病患者作为观察组，将同期于该院进行健康体检的35例健康者设为对照组，并根据HbA1c水平的高低将观察组患者分为A、B、C3组。给予所有患者HbA1c与U-mAlb检测，对比观察组与对照组患者HbA1c、U-mAlb水平及观察组中A、B、C3组间HbA1c与U-mAlb之间的关系。结果观察组HbA1c、U-mAlb水平均明显高于对照组差异有统计学意义（P＜0.05）；A、B、C3组U-mAlb水平随着HbA1c水平的升高而增加，差异有统计学意义（P＜0.05）。结论联合应用HbA1c与U-mAlb两项生化指标可较好的诊断糖尿病肾病病情，观察病情发展状况，具有重要的临床诊断价值。

糖尿病肾病；糖化血红蛋白；尿微量蛋白

［Abstract］Objective To analyze the clinical effect of the application of HbA1c and U-mAlb as the diagnostic indexes of diabetic nephropathy.Methods 35 cases of patients with diabetic nephropathy admitted and treated in our hospital from August 2014 to September 2015 were selected as the observation group，35 cases of health physical examiner in our hospital at the same period were selected as the control group，and the patients in the observation group were divided into the group A，the group B and the group C according to the HbA1c level，and all patients were given HbA1c and U-mAlb test，and the HbA1c，U-mAlb levels between the two groups and the correlation between HbA1c and U-mAlb between the three groups in the observation group were compared.Results The HbA1c and U-mAlb levels in the observation group were obviously higher than those in the control group，and the differences were obvious（P＜0.05），and the U-mAlb levels increased with the increase of HbA1c levels in the group A，group B and group C，and the differences were obvious（P＜0.05）.Conclusion The combined application of two biochemical indexes of bA1c and U-mAlb can better diagnose the diabetic nephropathy condition and observe the development of disease condition，which is of major clinical diagnosis value.

［Key words］Diabetic nephropathy；Glycosylated hemoglobin；Microalbuminuria

糖尿病肾病属于糖尿病常见的并发症之一，在很大程度上增加了糖尿病的死亡率［1］。但其早期临床症状往往具有较强的隐匿性，患者易于忽视病情，就诊时病情已严重恶化，使得治疗难度明显增加，同时也增大了患者家属及整个家庭的生活负担［2］。因此如何应用有效的生化指标及时诊断糖尿病肾病对于临床治疗十分关键。目前临床上多采用尿蛋白、血肌酐、尿素氮等指标作为诊断该病的主要依据［3］，但早期诊断结果常常不太理想，常导致病情延误。……