褚岩珺 李运伦

摘要：目的 探讨中医从脾胃论治失眠用药规律，为临床治疗失眠提供参考。方法 计算机检索中国知识资源总库（CNKI）、中国学术期刊数据库（万方数据）中从脾胃论治失眠的相关文献，录入中医传承辅助平台（V2.5），采用关联规则apriori算法、改进互信息法、复杂系统熵聚类等数据挖掘方法，分析从脾胃论治失眠的用药规律。结果 经筛选，共纳入处方87首，涉及药物165味。数据挖掘分析得出处方中高频药物30味，高频药物组合19组，药物关联规则4条，演化得到2味药药物组合13组，新处方3首。结论 中医从脾胃论治失眠以调理脾胃气机为法，常用药物以健脾化痰、清胃降逆、益气安神为主，可为临床治疗失眠提供参考。

关键词：失眠；脾胃论治；中医传承辅助平台；数据挖掘；用药规律

DOI：10.3969/j.issn.1005-5304.2016.07.013

中图分类号：R256.23；R2-05 文献标识码：A 文章编号：1005-5304（2016）07-0051-03

Analysis on Medication Principles of Formulas in Treating Insomnia from Spleen and Stomach Based on Literatures CHU Yan-jun1， LI Yun-lun2 （1. Shandong University of TCM， Jinan 250355， China； 2. Affiliated Hospital of Shandong University of TCM， Jinan 250011， China）

Abstract： Objective To discuss the medication principles of diagnosis and treatment for insomnia from spleen and stomach； To provide references for clinical treatment for insomnia. Methods Relevant articles about diagnosis and treatment forinsomnia from spleen and stomach were searched in CNKI and Wanfang Data through computers， the data were input into Traditional Chinese Medicine Inheritance Supporting System （V2.5） and then association rules， apriori arithmetic， improved mutual information method， and complex system entropy cluster methods were used to analyze the medication principles of diagnosis and treatment for insomnia from spleen and stomach. Results Through screening， totally 87 prescriptions were included， involving 165 herbal medicine. Data mining results showed that there were 30 high-frequency herbal medicine， 19 high-frequency medicinal combinations， and 4 medicinal association rules. Evolution led to 13 medicinal combinations of 2 herbal medicine and 3 new prescriptions. Conclusion The main method of diagnosis and treatment for insomnia from the spleen and stomach is regulating qi activity of spleen and stomach. The features of common medicine are invigorating spleen to reduce phlegm， clearing stomach and calming the adverse-rising energy， and tonifying qi and soothing nerves， which can offer references for clinical treatment for insomnia.

Key words： insomnia； spleen and stomach； Traditional Chinese Medicine Inheritance Supporting System； data mining； medication regularity

失眠，是以不能获得正常睡眠，睡眠时间、深度及消除疲劳作用不足为主的一种病症，为临床常见病、多发病。据估计，到2020年全球大约有7亿多失眠患者[1]。失眠属中医学“不寐”“不得眠”“不得卧”“目不瞑”等范畴，多认为病位在心，主要涉及脾、肝、肾。《素问·逆调论篇》提出“胃不和则卧不安”，后世医家对失眠与脾胃的关系也多有论述，为从脾胃论治失眠提供了理论依据。本研究应用中医传

通讯作者：李运伦，E-mail：li.yunlun@163.com

承辅助平台（V2.5）对中医从脾胃治疗失眠的现代文献进行收集、整理，分析其组方规律，挖掘其用药特点，从而为临床治疗及新药开发提供依据。

1 材料与方法

1.1 数据来源