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肝功与血脂血清学指标水平检验在脂肪肝诊断中的应用分析

2016-05-14付晓杰王璐

中外医疗 2016年6期
关键词:血脂

付晓杰 王璐

[摘要] 目的 探讨脂肪肝患者及健康者的血清中肝功能及血脂血清指标的差异,为早期临床诊断脂肪肝提供参考。 方法 随机选取2013年11月—2015年3月间收治的30例脂肪肝患者及30例健康者作为研究对象,使用AU5400模块化高通量全自动生化分析仪(罗氏)对患者血清中AST、ALT、TC、TG、HDL-C及LDL-C进行检测。再使用免疫抑制法对血清中AST水平进行检测,使用丙酮酸氧化酶法对ALT水平进行检测,而TC水平检测水平使用CHOD-PAP酶法进行检测。 结果 观察组和对照组受试者血清中AST和ALT水平分别为(81.56±6.82)、(57.23±7.88)和(41.18±6.21)、(25.98±5.89)U/L,观察组AST和ALT水平显著高于对照组(P<0.05);观察组受试者血清中TG、TC、HDL-C 以及LDL-C水平分别为(2.36±1.21)、(6.87±1.32)、(1.34±0.78)、(3.21±1.32)和(1.23±0.64)、(4.23±1.09)、(1.32±0.56)、(2.79±1.02)mmol/L,观察组TG、TC水平显著高于对照组(P<0.05),但HDL-C及LDL-C水平间差异无统计学意义(P>0.05);观察组受试者血清中ALT、AST、TG以及TC的阳性检检出率显著高于对照组(P<0.05),但两组间血清中HDL-C及LDL-C的阳性检出率差异无统计学意义(P>0.05),使用联合检测时观察组和对照组的阳性检出率分别为86.67%和3.33%,且观察组阳性检出率显著高于对照组(P<0.05)。 结论 对患者血清中多种生化指标进行检验,可以及时发现患者病情变化,值得在临床工作中进行评价。

[关键词] 肝功;血脂;血清学指标;脂肪肝

[中图分类号] R446.1 [文献标识码] A [文章编号] 1674-0742(2016)02(c)-0190-03

Application Analysis of Liver Function and Serum Lipid Level Test in Diagnosis of Hepatic Adipose Infiltration

FU Xiao-jie1, WANG Lu2

1.Hospital of Beihua University, Jilin, Jilin Province, 132013 China;2.Nanchang University, Nanchang, Jiangxi Province, 330006 China

[Abstract] Objective To discuss the difference in the liver function in serum and serum lipid index between patients with hepatic adipose infiltration and healthy people and provide reference for the early diagnosis of hepatic adipose infiltration in clinic. Methods 30 cases of patients with hepatic adipose infiltration and 30 cases of healthy people treated from November 2013 to March 2015 were selected as the research object, the AST, ALT, TC, TG, HDL-C and LDL-C in serum of the patients were detected by AU5400 modular high throughput automatic biochemical analyzer(Roche),then the AST level in serum was detected by immunosuppression, ALT level was detected by pyruvate oxidase method, and the TC level was detected by CHOD-PAP enzyme method. Results The AST and ALT level in the observation group were obviously higher than those in the control group, (81.56±6.82)U/L vs(41.18±6.21)U/L,(57.23±7.88)U/L vs(25.98±5.89)U/L, the TG and TC level in the observation group were obviously higher than those in the control group,(2.36±1.21)mmol/Lvs(1.23±0.64)mmol/L,(6.87±1.32)mmol/Lvs(4.23±1.09)mmol/L(P<0.05) but there was no obvious difference in the HDL-C and LDL-C level between the observation group and the control group,(1.34±0.78)mmol/L vs(1.32±0.56)mmol/L,(3.21±1.32)mmol/L vs(2.79±1.02)mmol/L(P>0.05), the positive detection rate of ALT, AST, TG and TC in serum in the observation group was obviously higher than that in the control group(P<0.05), the difference in the positive detection rate of HDL-C and LDL-C in serum between the two groups was not statistically significant (P>0.05),the positive detection rate in the observation group and the control group by combined detection was respectively 86.67% and 3.33%, and the positive detection rate in the observation group was obviously higher than that in the control group(P<0.05). The test of multiple biochemical indexes in serum in patients can find the changes of the patients condition, and it is worth evaluation in clinic.

[Key words] Liver function; Blood lipid; Serum index; Hepatic adipose infiltration

伴随着社会的迅速发展,人们的日常生活水平也随着日益升高,人们的日常生活方式以及饮食结构发生了巨大的变化,脂肪肝的临床发病率日益升高,目前以成为威胁我国人们生命健康安全的第二大肝病,但一般情况下脂肪肝患者基本无明显临床症状[1]。有学者指出,肝硬化患者其血清学指标与患者的肝脏受损程度密切相关,血清中其水平的变化可直接或间接反映患者肝脏受损程度[2]。该研究随机选取该院2013年11月—2015年3月间收治的30例脂肪肝患者进行分析,探讨脂肪肝患者及健康者的血清中肝功能及血脂血清指标的差异,为早期临床诊断脂肪肝提供参考,现报道如下。……

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