吴燕，金芳梅甘肃省中医院，甘肃兰州730050



针灸联合甲氨喋呤治疗类风湿性关节炎53例

吴燕，金芳梅
甘肃省中医院，甘肃兰州730050

［摘要］目的：观察针灸联合甲氨喋呤治疗类风湿性关节炎(rheumat oi d art hri t i s，RA)的临床疗效。方法：将106例RA患者随机分为观察组、对照组各53例，观察组给予针灸联合甲氨喋呤治疗，对照组给予甲氨喋呤治疗。疗程均为4个月，观察2组临床症状、实验室指标和不良反应。结果：总有效率观察组为88.68％，对照组为71.70％，2组比较差异有统计学意义(P＜0.05)。疼痛程度评分、晨僵时间、双手握力、15 m步行时间、血沉(ESR)、C反应蛋白(CRP)、类风湿因子(RF)等指标2组治疗后均明显改善(P＜0.05)，观察组改善更明显(P＜0.05)。2组不良反应发生率差异无统计学意义(P＞0.05)。结论：针灸联合甲氨喋呤治疗RA有较好的临床疗效和安全性。

［关键词］关节炎，类风湿性；针灸；甲氨喋呤

Treating 53 Cases of Rheumatoid Arthritis by Acupuncture and Methotrexate

WU Yan,JIN Fangmei
Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China

Abstract Objective:To observe curative effects of acupuncture jointed with methotrexate in the treatment for rheumatoid arthritis (RA).Methods:All 106 patients were divided into the observation group and the control group,53 cases each group,the observation group accepted acupuncture and methotrexate,the control group methotrexate only.Both groups were treated for four months.Clinical symptoms,lab indexes and adverse reaction of both groups were observed.Results:Total effective rate of the observation group was 88.68％,higher than 71.70％ of the control group,the difference had statistical meaning (P＜0.05).Pain degree scales,morning stiffness time,hand grip,15m walking time,erythrocyte sedimentation rate (ESR),C-reactive protein (CRP),rheumatoid factors (RF) and others improved significantly after treating in both groups (P＜0.05),the improvement of the observation group was more obvious (P＜0.05).There was no significant difference in the comparison of the incidence of adverse reaction between both groups (P＞0.05).Conclusion:Acupuncture jointed with methotrexate in the treatment for rheumatoid arthritis (RA) show better clinical effects and safety.

Keywords arthritis,rheumatoid;acupuncture;methotrexate

类风湿性关节炎(rheumatoid arthritis，RA)是一种慢性、进行性、侵袭性疾病，主要表现为对称性、多关节炎。目前，西药治疗RA虽可以取得一定疗效，但常需联合用药，有较大副作用，且临床效果不佳［1-2］。针灸治疗本病具有疗效显著、无明显副作用的优点。近年来，笔者采用针灸联合甲氨喋呤治疗类风53例RA患者，临床疗效满意，现报道如下：

1　资料与方法

1.1临床资料将在甘肃省中医院就诊的106 例RA患者随机分为2组。观察组53例，其中男14例，女39例；年龄25～68岁，平均39.9岁；病程1～28年，平均8.3年。对照组53例，其中男15例，女38例；年龄24～69岁，平均41.1岁；病程1～26年，平均7.9年。2组患者性别、年龄、病程等临床资料比较，差异无统计学意义(P＜0.05)，具有可比性。

1.2纳入标准纳入：1)符合类风湿性关节炎诊断标准；……