黄亚雄，张元珍



·综述·

Krüppel样因子家族在女性生殖系统疾病中的研究进展

黄亚雄，张元珍△

女性生殖系统疾病很大程度上与雌、孕激素及其受体介导信号通路失调所致细胞增殖、凋亡和分化异常有关。这些核受体的精细调控是复杂的，许多核因子参与其中。Krüppel样因子（Krüppel-like factors，KLFs）是一组与真核细胞转录调控密切相关的锌指蛋白，在女性生殖系统中普遍表达，作为类固醇激素反应的共同调控者和整合者。KLF4在子宫内膜异位症（EMs）患者的在位内膜和子宫内膜肿瘤中表达减少。围着床期，KLF5在子宫内膜容受性的形成中起重要作用，与胚胎成功植入有关。KLF6参与胎盘发育和妊娠的维持。KLF9对孕激素受体起正向调节作用，而对雌激素受体起到负向调节作用。KLF11是一种转录抑制因子，具有潜在地抑制子宫肌瘤、EMs异位病灶生长的功能。深入探讨KLFs的生物功能，对认识女性生殖系统疾病的发病机制有重要意义。

Kruppel样转录因子类；锌指；女（雌）性泌尿生殖系统疾病；子宫内膜

【Abstract】The diseases of female reproductive system were partially related to the abnormal cell proliferation，apoptosis and differentiation which is due to the imbalance between estrogen and progesterone，as well as their receptor-related signaling pathways.The complicated regulation of those nuclear receptor-related signaling pathways ismediated bymany nuclear factors，such as Krüppel-like factors（KLFs）.KLFs are a group of zinc finger proteins，which is closely related to the transcriptional regulation of eukaryotic cells.KLFs are ubiquitously expressed in female reproductive tissues，as the critical co-regulator and integrator of steroid hormone actions.Expression of KLF4 is decreased in the eutopic endometrium in patientswith endometriosis（EMs）and in the endometrial cancer tissues.In peri-implantation stage，KLF5 plays an important role in the formation of the receptivity of endometrium which is associated with successful embryos implantation.KLF6 is involved in the development of placenta and the maintenance of pregnancy.KLF9 plays a positive role in the regulation of progesterone receptor and a negative role in the regulation of estrogen receptor.KLF11 as a transcription inhibitor has the potential to inhibit the growth of uterine fibroids and EMs ectopic lesions.It is helpful to study the biological function of KLFs for understanding the pathogenesis of female reproductive diseases.

【Keywords】Kruppel-like transcription factors；Zinc fingers；Femaleurogenitaldiseases；Endometrium

（JIntReprod Health/Fam Plan，2016，35：348-352）

基金项目：国家自然科学基金（81370707）

作者单位：430071武汉大学中南医院（黄亚雄，张元珍）；湖北医药学院附属东风医院（黄亚雄）

通信作者：张元珍，E-mail：zhangyuanzhen@vip.sina.com

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审校者

转录因子是一类具有重要功能的DNA结合蛋白，其分子结构上的特异结构域，通过激活或抑制其下游基因的转录，调节细胞的增殖、凋亡、分化等生理过程，在调控细胞及组织的基因表达模式及时相方面起着重要作用。Krüppel样因子（Krüppel-like factors，KLFs）就属于这类转录因子［1］，KLFs家族的许多成员都与生殖系统疾病有关［2］。……