蒋欣，徐阳



卵母细胞的葡萄糖代谢研究进展

蒋欣，徐阳△

卵母细胞发育潜能受到其生长微环境的影响，因此对卵母细胞生长微环境的研究是生殖医学关注的热点。卵丘细胞、卵泡液等与卵母细胞紧密相联，组成卵母细胞生长微环境，为卵母细胞能量代谢提供所需物质，同时也分泌激素类物质、细胞活化因子等调节卵母细胞的生长发育。因此卵母细胞生长的微环境，与卵母细胞的质量有关。目前，关于卵母细胞生长微环境的研究很多，但不能忽略与其联系紧密的卵母细胞本身，由于科学技术及道德伦理的限制，对卵母细胞本身的代谢研究较少。更好地了解卵母细胞自身的代谢过程，才能明白生长微环境与卵母细胞的联系，及微环境如何影响调控卵母细胞的生长发育。综述卵母细胞的葡萄糖代谢，分别从葡萄糖的转运、代谢途径、代谢相关酶、葡萄糖与卵母细胞质量的关系4个方面阐述。

卵母细胞；葡萄糖代谢障碍；生殖医学；葡萄糖；代谢网络和途径

【Abstract】The developmental competence of oocyte is influenced by its growthmicroenvironment，which is one of the research hotspots in human reproductionmedicine.Cumulus cells，follicular fluid and others，are closely related with oocyte development and maturation bymaking up themicroenvironment of oocyte，providingmetabolic substances required for oocyte，and by secreting some hormonal substances and cell activation factors.Therefore，thismicroenvironment is very important for the growth and development of oocyte，which is related with the quality of oocyte.There are a lotof researches on themicroenvironment of oocyte.However，due to limitations of scientific technology and ethics，we know little about the metabolism of oocytes own，which is related with its microenvironment closely.A better understanding of oocytes own metabolic processes，we can understand how the growth microenvironment of the oocyte contact with oocyte，and how it affects the regulation of growth and development of oocytes.In this review，we try to introduce the glucose metabolism in oocyte，including four aspects:glucose transport，metabolic pathways，metabolic enzymes and the relationship between glucose and quality of oocyte.

【Keywords】Oocytes；Glucosemetabolism disorders；Reproductivemedicine；Glucose；Metabolic networksand pathways

（JIntReprod Health/Fam Plan，2016，35：295-298）

近几年来，卵母细胞的生长微环境是生殖医学研究的热点问题。卵母细胞的发育成熟及排卵过程受到其生长微环境的调节，这包括激素水平、细胞因子、代谢物质等多个方面。在临床中，获得高质量的卵母细胞对今后胚胎质量和临床妊娠结局有直接影响。目前，对卵母细胞质量的评估大部分还是从显微镜下的形态学评估，缺乏系统全面性，而对卵母细胞代谢的研究或许能为卵母细胞的质量评估提供一种新的方式［1］。……