18F—FDG PET/CT在非小细胞肺癌诊断与分期中的应用价值
2016-03-12智生芳黄晓红毕伟李霞霞张伟标
智生芳 黄晓红 毕伟 李霞霞?张伟标
[摘要] 目的 探讨18F-FDG PET/CT在非小细胞肺癌诊断与分期中的应用价值。 方法 选取我院初诊非小细胞肺癌的患者175例,全部患者均采用PET/CT检查,比较PET与PET/CT对非小细胞肺癌诊断与分期的评估价值。 结果 PET/CT对非小细胞肺癌的诊断灵敏度、特异度、阳性预测值、阴性预测值与准确度分别为95.51%, 91.86%,92.39%,95.18%,93.71%;PET对非小细胞肺癌的诊断灵敏度、特异度、阳性预测值、阴性预测值与准确度分别为75.29%,73.33%,72.73%,75.86%,74.29%;PET/CT对非小细胞肺癌的诊断灵敏度、特异度、阳性预测值、阴性预测值与准确度均明显高于PET,两种检查方法比较,差异有统计学意义(P<0.05)。Ⅲ期非小细胞肺癌患者SUVmax值明显高于Ⅰ、Ⅱ期,Ⅱ期小细胞肺癌患者SUVmax值明显高于Ⅰ期,不同临床分期比较,差异有统计学意义(P<0.05)。 结论 PET/CT在非小细胞肺癌诊断与分期中具有重要的应用价值,值得临床推广应用。
[关键词] 18F-FDG;PET/CT;非小细胞肺癌;诊断;分期
[中图分类号] R734.2;R730.44 [文献标识码] B [文章编号] 2095-0616(2016)01-174-04
[Abstract] Objective To discuss the application value of 18F-FDG PET/CT in the diagnosis and staging of small cell lung cancer. Methods 175 newly diagnosed non small cell lung cancer patients in our hospital were selected,all patients were examined by PET/CT,the diagnosis and staging value of non small cell lung cancer were compared between PET and PET/CT. Results The diagnostic sensitivity, specificity, positive predictive value and accuracy of PET/CT were 95.51%,91.86%,92.39%,95.18%,93.71%,the diagnostic sensitivity,specificity,positive predictive value and accuracy of PET were 75.29%,73.33%,72.73%,75.86%,74.29%,the difference was statistically significant (P<0.05).SUVmax in stage III non-small cell lung cancer patients was significantly higher than stage I and II, and SUVmax value in stage II was significantly higher than stage I.The difference was statistically significant (P<0.05). Conclusion PET/CT has important application value in the diagnosis and staging of non-small cell lung cancer.It is worthy of clinical application.
[Key words] 18F-FDG;PET/CT;Non small cell lung cancer;Diagnosis;Staging
非小细胞肺癌是常见的呼吸道恶性肿瘤之一,其生物学特征较为复杂,恶性程度较高[1]。大部分非小细胞肺癌在确诊时已经处于Ⅲ期或Ⅳ期。相关文献证实,早期诊断与早期准确的临床分期在制定治疗方案,延长生存期与提高生活质量中具有重要的意义[2]。目前,随着医学影像学技术的发展,影像学检查在非小细胞肺癌的诊断中具有重要的价值。其中CT常规扫描范围的影响,难以清晰显示全部病灶组织[3]。本研究探讨PET/CT在非小细胞肺癌诊断与分期中的应用价值,现报道如下。
1 资料与方法
1.1 一般资料
选取我院2012年1月~2015年1月期间初诊非小细胞肺癌的患者175例,其中男100例,女75例,年龄:46~78岁,平均(59.8±6.5)岁,病程3个月~2年,平均(1.25±0.25)年。纳入标准:全部患者均符合非小细胞肺癌的临床诊断标准[4],对本研究知情同意并签署知情同意书。……
