逯双　杨培民　曹广尚

摘要：白花蛇舌草具有抗肿瘤、抗氧化、免疫调节等多种药理活性。本文通过收集整理近年来国内外相关文献，发现其发挥药效的主要活性成分多糖及黄酮具有不同程度的一致性，并对二者活性成分的药理作用、提取纯化工艺进行归纳总结。尽管迄今对白花蛇舌草黄酮和多糖药效及提取研究已取得一定成果，但多以黄酮或多糖单一成分作为研究对象，对白花蛇舌草发挥药效的机理探索尚不够深入，对其成分的提取纯化工艺指标较为单一。本文结合肠道菌群的吸收代谢、药物结构与发挥药效的关系多角度推测其作用机制，展望以多指标提取工艺进行优化，为进一步开发利用白花蛇舌草提供参考。

关键词：白花蛇舌草；多糖；黄酮；综述

DOI：10.3969/j.issn.1005-5304.2016.03.037

中图分类号：R285 文献标识码：A 文章编号：1005-5304（2016）03-0122-04

Abstract：Herba Hedyotis Diffusae has many kinds of pharmacological activities such as anti-tumor， antioxidant， immune regulation and so on. This article collected and reported the related literature at home and abroad in recent years， found that pharmacological active ingredients of Herba Hedyotis Diffusae show consistency of polysaccharides and flavonoids to varying degrees， and summarized the pharmacological effects and extraction and purification process. The author believed that， the study about Herba Hedyotis Diffusae has made relatively great achievements， but the research mainly focused on polysaccharides or flavonoids， and efficacy of Herba Hedyotis Diffusae was not in enough in-depth exploration. The indicator of extraction and purification process is relatively single. This study estimated the mechanism of Herba Hedyotis Diffusae from the aspects of absorption and metabolism of intestinal flora and relationship between medicine structure and exert efficacy， hoping to optimize the extracting processes by multiple indexes， and provided references for further exploitation and utilization of Herba Hedyotis Diffusae.

Key words：Herba Hedyotis Diffusae； polysaccharides； flavones； review

白花蛇舌草为茜草科植物白花蛇舌Oldenlandia diffusa（Willd.）Roxb.的干燥全草[1]。其味苦、甘，性寒，归心、肝、脾经，具有清热解毒、利尿消肿、抗癌止痛功效。临床上白花蛇舌草主要用于抗肿瘤、抗菌消炎，其多糖和黄酮类均为发挥药效作用的活性成分[2]。笔者通过整理、归纳相关研究成果，发现其在药效上具有不同程度的一致性，而相关报道只针对白花蛇舌草黄酮和多糖的单体成分，对二者间是否存在相互作用的研究不多。为此，笔者通过对白花蛇舌草黄酮和多糖成分药理作用的归纳总结，探索其发挥药效的联系，推断其相互作用机制，并综述二者的提取纯化工艺研究，展望黄酮与多糖成分提取工艺中有关问题，为白花蛇舌草的进一步研究提供参考。……