高淑林　王浩　袁美锦

重组人干扰素α－2b联合炎琥宁对手足口病患儿炎性反应和免疫功能的影响

高淑林王浩袁美锦

【摘要】目的探讨重组人干扰素α－2b联合炎琥宁对手足口病患儿炎性反应、免疫功能的影响。方法选取2014年1月至2015年1月收治的手足口病患儿120例，随机分为观察组和对照组，每组60例，对照组给予利巴韦林治疗，观察组给予重组人干扰素α－2b和炎琥宁治疗。比较2组临床疗效、症状、体征改善时间、炎性因子［肿瘤坏死因子－α(TNF－α)、白介素－6(IL－6)、白介素－10(IL－10)］、T淋巴细胞亚群(CD3+、CD4+、CD8+、CD4+/CD8+)及免疫球蛋白(IgA、IgG、IgM)变化。结果观察组总有效率显著高于对照组，差异有统计学意义(P＜0.05)。与对照组比较，观察组症状、体征改善时间显著缩短，差异有统计学意义(P＜0.05)。与治疗前比较，治疗后2组CD4+、CD4+、CD4+/CD8+、IgA、IgG、IgM水平显著升高，CD8+、TNF－α、IL－6、IL－10水平显著降低，差异有统计学意义(P＜0.05)，但观察组改善程度优于对照组，差异有统计学意义(P＜0.05)。结论重组人干扰素α－2b联合炎琥宁治疗手足口病疗效确切，能有效减轻善患儿炎性反应，增强细胞免疫及体液免疫功能。

【关键词】手足口病;重组人干扰素α－2b;炎琥宁;炎症反应;免疫功能

【中图分类号】R 725.125.7

【文献标识码】A

【文章编号】1002－7386(2015)18－2732－04

doi:10.3969/j.issn.1002－7386.2015.18.003

【Abstract】Objective To investigate the effects of recombinant human interferon α－2b combined with potassium sodium dehydroandroan drographolide succinate on inflammatory reaction and immune function in children patients with hand－foot－and －mouth disease(HFMD).Methods One hundred and twenty children patients with HFMD who were admitted into our hospital from January 2014 to January 2015 were randomly divided into observation group(n =60)and control group(n =60).The patients in control group were treated with ribavirin，however，the patients in observation group，on the basis of symptomatic treatment，were given recombinant human interferon α－2b combined with potassium sodium dehydroandroan drographolide succinate.The clinical efficacy，improvement time of clinical symptoms，the changes of serum inflammatory cytokines including TNF－α，IL －6，IL－10，T lymphocyte subsets(CD3+，CD4+，CD8+，CD4+/CD8+)，immunoglobulins(IgA，IgG，IgM)in both groups before and after treatment were observed and compared.Results The total effective rate(88.33%)in observation group was significantly higher than that(70.0%)in control group(P＜0.05).As compared with that in control group，the improvement time of clinical symptoms was significantly shortened in observation group(P＜0.05).As compared with those before treatment，the serum levels of CD3+，CD4+，CD4+/CD8+，IgA，IgG，IgM in both groups were significantly increased after treatment，however，the serum levels of CD8+，TNF－α，IL－6，IL－10 were significantly decreased in both groups(P＜0.05)，moreover，the improvement degree in observation group was superior to that in control group(P＜0.05).Conclusion Recombinant human interferon α－2b combined with potassium sodium dehydroandroan drographolide succinate is effective in treating HFMD in children，which can effectively relieve patient’s inflammatory reaction and can enhance patient’s cellular immune and humoral immune function.

作者单位: 075000河北省张家口市，河北北方学院附属第一医院感染科(高淑林、王浩)，护理部(袁美锦)

Effects of recombinant human interferon α－2b combined with potassium sodium dehydroandroan drographolide succinate on in-flammatory reaction and immune function in children patients with hand－foot－and－mouth disease GAO Shulin*，

WANGHao*，YUAN Meijin.*Department of Infectious Diseases，The First Hospital Affiliated to Hebei North College，Hebei，Zhangjiakou 075000，China

【Key words】hand－foot－and－mouth disease; recombinant human interferon α－2b; potassium sodium dehydroandroan drographolide succinate; inflammatory reaction; immune function

手足口病是由肠道病毒71型、柯萨奇A组16型等多种肠道病毒引起的小儿急性传染病，多见于5岁以下学龄前儿童，经呼吸道、消化道、密切接触传播，夏、秋季节多发［1］。主要临床表现为发热、手足、口腔黏膜、臀部等部位出现溃疡、疱疹、斑丘疹，可出现脑炎、脑脊髓膜炎、神经源性肺水肿、肺出血、心力衰竭等严重并发症，最终死亡。……