作者单位：510080 广州，广东药学院附属第一医院核医学科

甲亢及甲减患者血清瘦素水平与甲状腺激素相关性研究

刘一鸣李丽何伟波孙慧琳

【摘要】目的研究甲状腺功能亢进(甲亢)、甲状腺功能减退(甲减)患者及正常人中血清瘦素水平及其与甲状腺激素的关系。方法选取正常体质量的甲亢患者29例(甲亢组)、甲减患者22例(甲减组)、健康体检合格者35名(正常对照组)。采用电化学发光法检测血清FT3、FT4和TSH； 采用放射免疫法检测血清瘦素水平。结果甲亢患者血清瘦素水平(10.01±5.67)ng/ml高于对照组(5.36±2.11)ng/ml及甲减组(5.40±1.99)ng/ml(P均<0.01)；甲减组瘦素水平与对照组比较差异无统计学意义 (P>0.05)。Pearson 相关分析显示，瘦素与FT3、FT4呈正相关 (FT3：r=0.728, P<0.01；FT4： r=0.776, P<0.01)，而与BMI和TSH无显著相关性(P>0.05)。结论血清瘦素水平在甲亢患者中高于正常，与FT3、FT4呈正相关，提示瘦素的表达与甲状腺功能状态具有一定的相关性。

【关键词】甲状腺功能亢进；甲状腺功能减退；瘦素

DOI:10.3969/g.issn.0253-9802.2015.06.010

通讯作者，孙慧琳，E-mail: sun-hui-lin@126.com

收稿日期：(2014-12-06)

Correlation between serum leptin levels and thyroid hormone levels in patients with hyper- and hypothyroidismLiuYiming,LiLi,HeWeibo,SunHuilin.DepartmentofNuclearMedicine,theFirstAffiliatedHospitalofGuangdongPharmaceuticalUniversity,Guangzhou510080,China

Correspondingauthor,SunHuilin,E-mail:sun-hui-lin@126.com

Abstract【】ObjectiveTo study the correlation between serum leptin levels and thyroid hormones concentration in patients with hyper- and hypo-thyroidism, and healthy subjects. MethodsTwenty nine hyperthyroid patients with normal weight (hyperthyroidism group), 22 hypothyroid cases (hypothyroidism group) and 35 healthy controls (control group) were recruited in this investigation. Serum thyroid-stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxine (FT4) levels were measured with electrochemiluminescent immunoassay (ECLIA) method. Serum leptin level was assessed by radio-immunoassay (RIA). Results The serum leptin level in hyperthyroid patients was (10.01±5.67) ng/mL, significantly higher compared with (5.36±2.11) ng/mL in healthy controls and(5.40±1.99)ng/mL in hypothyroid patients(both P<0.01). The serum leptin levels did not significantly differ between the hypothyroid and control groups (P>0.05). Pearson correlation analysis revealed that serum leptin level was positively correlated with FT4 and FT3 levels (FT3: r=0.728, P<0.01; FT4: r=0.776, P<0.01), but had no correlation with BMI and TSH. ConclusionsSerum leptin level in hyperthyroid patients was higher than that in normal controls. Leptin level was positively correlated with FT3 and FT3 levels, suggesting that leptin expression was associated with thyroidal function to certain extent.

【Key words】Hyperthyroidism; Hypothyroidism; Leptin

瘦素是由Halaas在1995年命名，由 ob基因在脂肪组织特异性表达、合成和分泌的由167个氨基酸组成的蛋白激素[1-2]。瘦素作为脂肪组织分泌的一个重要的细胞因子，调节人体体质量和能量平衡，在糖和脂肪代谢、神经内分泌起重要的作用[3]。重组瘦素作为先天性全身性脂肪代谢不良疾病的治疗已得到了批准，瘦素在下丘脑-垂体-甲状腺轴的调节作用方面也在研究探索中[4-5]。本文通过检测甲状腺功能异常患者血清瘦素水平变化，探讨甲状腺激素与瘦素的相互关系。

对象和方法

一、研究对象

根据甲状腺疾病诊断标准，所有成年患者来自广州药学院附属第一医院核医学门诊，其中甲状腺功能亢进(甲亢组)29例，男5例，女24例，年龄(34.8±10.1)岁；……