止痒方治疗糖尿病皮肤瘙痒症临床研究※

杨祝辉李敬华1王汝心2

(河北省抚宁县人民医院皮肤科，河北抚宁066300)

【摘要】目的观察止痒方治疗糖尿病皮肤瘙痒症的临床疗效。方法将165例糖尿病皮肤瘙痒症患者随机分为2组，治疗组80例，对照组85例。2组均予糖尿病常规治疗，治疗组联合止痒方治疗，对照组联合地氯雷他定分散片治疗。均连续治疗4周后，对2组临床症状瘙痒程度、面积、发作频率及持续时间进行量化积分统计，比较2组治疗前后症状积分差值及总积分变化，并统计疗效。结果2组治疗后临床症状总积分与本组治疗前比较均有明显下降(P<0.05)，且治疗组下降更明显(P<0.05)；2组治疗后各项症状积分差值比较差异均有统计学意义(P<0.05)，治疗组差值大于对照组；2组总有效率比较差异有统计学意义(P<0.05)，治疗组疗效优于对照组。结论止痒方治疗糖尿病皮肤瘙痒症疗效确切，可明显改善患者临床症状，安全性好，有推广应用价值。

【关键词】瘙痒症；糖尿病并发症；中药疗法

doi：10.3969/j.issn.1002-2619.2015.06.007

【中图分类号】R289.61；R587.29

【文献标识码】A

【文章编号】1002-2619(2015)06-0821-03

Abstract【】 Objective To observe the clinical effects of a self-made decoction for relieving itching on diabetic skin pruritus. Methods 165 patients with diabetic skin pruritus were divided into two groups. There were 80 patients in treatment group，and 85 patients in control group. Patients in treatment group were treated by a self-made decoction for relieving itching combined diabetic conventional treatments. Patients in control group were treated by desloratadine combined diabetic conventional treatments. All patients were treated continuously for 4 weeks. The symptoms of itch degree，itching area，occurrence frequency and duration were analyzed quantitative integral statistics in two groups. The integral differences of symptom score between before and after treatment were compared in two groups as well as total integral changes，and the clinical effects were analyzed. Results The total score of clinical symptoms after treatment were obviously decreased in two group (P<0.05)，and the decrease in treatment group was more obvious as compared with that in control group (P<0.05). There were significant differences between before and after treatment on symptom score difference in two groups (P<0.05)，the difference in treatment group was greater than that in control group.The total effective rate in treatment group was superior to that in control group (P<0.05). ConclusionThe traditional Chinese medicine of a self-made decoction for relieving itching has an exact effect on diabetic skin pruritus，can significantly improve the clinical symptoms，security and is worthy of popularizing.

作者简介：杨祝辉(1974—)，男，主治中医师，学士。从事皮肤病诊断与治疗工作。

收稿日期：(2014-03-26)

Clinical observation of a self-made decoction for relieving itching on diabetic skin pruritusYANGZhuhui*，LIJinghua，WANGRuxin.*DepartmentofDermatology，FuningCountyPeople'sHospitalinHebeiProvince，Hebei，Funing066300

【Key words】Pruritus；Diabetic complications；Traditional Chinese medical herbal treatment

※项目来源：2013年秦皇岛市科学技术研究与发展计划项目(第二批)(编号：201302A205)

1河北省抚宁县中医院内分泌科，河北抚宁066300

2河北省抚宁县中医院针灸科，河北抚宁066300

糖尿病皮肤瘙痒症是指糖尿病患者无原发性皮损，而出现以皮肤瘙痒为主要表现的皮肤疾病，可伴有抓痕、结痂、继发湿疹样变或苔藓样变等临床表现[1-2]，是糖尿病常见并发症之一，发病率可达7%~43%[3]，病情严重者全身瘙痒，给患者带来严重心理负担，对工作和日常生活产生严重影响。目前，西医多采用抗组胺药物对症处理，虽能暂时缓解症状，但总体疗效尚不满意。2011-01—2013-01，我们在糖尿病常规治疗基础上联合止痒方治疗糖尿病皮肤瘙痒症80例，并与地氯雷他定分散片治疗85例对照观察，结果如下。……