六味地黄汤治疗老年2型糖尿病肾病的临床观察

封三花李海风钱金花

摘要目的：探讨六味地黄汤治疗老年2型糖尿病肾病的临床疗效。方法：将120例老年2型糖尿病肾病患者随机等分为对照组和治疗组。对照组予以常规西医治疗， 治疗组在对照组治疗的基础上加用六味地黄汤。两组均治疗3个疗程后统计临床综合疗效， 并观察两组治疗前后中医证候评分、空腹血糖(FBG)、餐后2 h血糖(PBG)、糖化血红蛋白(HbAlc)、24 h尿白蛋白排泄率(UAE)、内生肌酐清除率(Ccr)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)。结果：治疗组患者临床综合疗效优于对照组(P<0.05)。治疗组治疗后中医证候评分、UAE、Ccr均低于对照组(P<0.05)。两组患者治疗前后FBG，PBG，HbAlc，TC，TG，HDL-C及LDL-C经比较有统计学意义(P<0.05)，两组治疗后各项经比较均无统计学意义(P>0.05)。结论：六味地黄汤治疗老年2型糖尿病肾病患者临床疗效确切。

关键词糖尿病肾病；六味地黄汤；中药疗法doi:10.3969/j.issn.1672-9676.2015.08.003

收稿日期：(2014-08-08)

收稿日期：(2015-06-02)

Clinical effect of Liuwei Dihuang decoction treatment elderly type 2 diabetic nephropathy

FENG San-hua,QIAN Jin-hua(Hebei Provincial Traditional Chinese Medicine Hospital,Shijiazhang050011)

LI Hai-feng(Fourth Hospital of Hebei Medical University,Shijiazhuang050000)

AbstractObjective:To investigate the effect of Liuwei Dihuang decoction treatment of elderly type 2 diabetic nephropathy.Methods:120 elderly patients with type 2 diabetes nephropathy patients randomly divided into control group and treatment group.The control group received routine western medicine treatment,while the treatment group on the basis of control group therapy plus soup of Liuwei Dihuang flavour glutinous rehmannia.To observe the clinical treatment effect after 3 course,and to observe TCM syndrome score,fasting blood glucose (FBG),2 h postprandial blood glucose (PBG),glycosylated hemoglobin (HbAlc),24 h urinary albumin excretion (UAE),endogenous creatinine clearance rate (Ccr),total cholesterol (TC),triglyceride (TG), high-density lipoprotein cholesterol (HDL-C)and low density lipoprotein cholesterol (LDL-C)of the two groups before and after treatment .Results:The treatment group patients clinical comprehensive curative effect was better than that of control group (P<0.05).The treatment group after treatment of TCM syndrome score,UAE,Ccr were lower than the control group(P<0.05).Two groups of patients before and after treatment of FBG,PBG,HbAlc,TC,TG,HDL and LDL-C-C by comparison with statistical significance (P<0.05),but after treatment there was no statistical significance (P>0.05) between two groups.Conclusion:Liuwei Dihuang decoction treatment clinical curative effect of elderly patients with type 2 diabetic nephropathy.

Key wordsDiabetic nephropathy;Liuwei Dihuang decoction;Traditional Chinese medicine therapy

糖尿病肾病发生率有增加趋势，病情较轻者降低生活质量，给患者家庭带来巨大的人力、财力负担，重者甚至威胁患者的生命。近年来科研工作者从延缓糖尿病肾病发展进程的角度出发，发现血管紧张素转换酶抑制剂有一定作用，但并不能起决定性的防治作用。当糖尿病肾病发展到进入持续性蛋白尿出现的临床期后，糖尿病肾病进程则难以逆转，目前在西药方面尚无特效治疗药物。随着现代中医药事业的发展，中医药在治疗糖尿病肾病，尤其是糖尿病肾病早期显示出一定的优势。因此我们运用六味地黄汤治疗老年2型糖尿病肾病60例，并与西医常规治疗的60例患者进行对照，现将结果报道如下。……