技术方法

大鼠尾静脉留置针固定方法的改进

杨敏 ，陈历健，王瑞敏，李佟玲

(重庆医药高等专科学校护理学院基础护理教研室，重庆401331)

【摘要】目的探讨静脉留置针在清醒大鼠尾静脉的留置时间。 方法 将100只Wistar大鼠随机分为两组，即实验组和对照组，采取相同的方法分别进行尾静脉留置针穿刺和置管，对照组采取传统的固定方法，即用3M透明敷贴固定；实验组在此基础上，再用厚约0.1 mm的铝合金皮套管环形包裹在留置针外侧，分别记录留置时间。 结果 实验组大鼠尾静脉留置针的留置时间为 (166.86±9.03)h，对照组的留置时间为(20.24±5.04) h，两组留置时间相比较，差异明显有统计学意义(P0.01)。 结论改良的固定方法安全可靠，能够延长静脉留置针的留置时间，为静脉留置针并发症的实验研究提供了一定的基础。

【关键词】大鼠；尾静脉；静脉留置针；留置时间

[作者简介]杨敏(1979-)，女，讲师，硕士，主要从事基础护理教学工作，Email：xueymin@qq.com。

【中图分类号】R332【文献标识码】 A

doi:10.3969.j.issn.1671.7856. 2015.001.015

An improved fixation method of the indwelling

needle inserted in the rat tail vein

YANG Min，CHEN Li-jian，WANG Rui-min，LI Tong-ling

(Nursing Department of Chongqing Medical and Phamaceutical College, Chongqing 401331, China)

Abstract【】ObjectiveTo improve the fixation method of indwelling needle inserted in the tail vein in rats to keep the inserted needle for a longer indwelling time. Methods One hundred healthy Wistar rats (age 5～6 months, male:female=1:1) were randomly divided into two groups: the experimental group and the control group. Rats in both groups received the same tail vein indwelling needle puncture and cannulation. The control group got the traditional fixation, namely fixed by sticking with 3M transparent dressing paste. The experimental group received in addition to the traditional fixation, a 0.1 mm-thick aluminum tube placed outside the needle fixation site. The indwelling time in the rats were recorded and analyzed. ResultsThe indwelling time was (166.86±9.03) h and (20.24±5.04) h in the experimental and control groups, respectively (t =68.546, P0.01). ConclusionsOur improved method is safe and reliable. It can prolong the indwelling time of the punctured intravenous indwelling needle, and provides a useful rat model in studies on the complications of intravenous indwelling needle kept for a longer time.

【Key words】Rat；Tail vein； Intravenous indwelling needle；Indwelling time

静脉留置针凭借其优势在医学领域得到了越来越广泛的应用，常常用于静脉连续给药的实验研究和患者的连续给药治疗，但由此带来的并发症也引起了广大科研工作者的普遍重视，其中，最常见的就是静脉炎和静脉血栓[1]。近年来对静脉留置针留置时间及其并发症的相关研究也较多，但动物实验研究相对较少，而且多局限于实验兔，加上实验成本的原因，许多样本量也较小，很难为临床提供精确的留置时间参考。为探讨静脉留置针在大鼠实验研究中的可行性，笔者于2014年6～7月对100只成年大鼠的尾静脉进行了静脉留置针穿刺，旨在了解其保留时间，为今后留置针连续给药及其并发症的实验研究提供依据。……