丙戊酸镁辅助利培酮治疗精神分裂症阴性症状的疗效探讨
2015-10-21黎彪
黎彪
【摘要】目的:探究丙戊酸镁辅助利培酮对精神分裂症阴性症状的治疗效果。方法:对66例精神分裂阴性症状患者随机分为两组:观察组采用丙戊酸镁合用利培酮治疗,对照组单用利培酮治疗。比较两组患者的临床效果及不良反应。结果:经治疗,观察组患者的治疗总有效率明显大于对照组,差异具有统计学意义(P<0.05);对比两组患者治疗后的不良反应,无明显统计学差异(P>0.05)。结论:丙戊酸镁辅助利培酮对精神分裂症阴性症状患者进行治疗,具有良好的治疗效果,值得在临床中推广应用。
【关键词】丙戊酸镁;利培酮;精神分裂;阴性症状
【Abstract】Objective To explore the clinical efficacy of magnesium valproate combined with risleridone in treating the negative symptoms of schizophrenia. Methods 66 cases of schizophrenia with negative symptoms were randomly divided into two groups, the observation group and the control group. The observation group was treated with magnesium valproate combined with risperidone while the control group was treated with risperidone alone. Then, clinical effects and adverse reactions were compared between the two groups. Results The total effective rate in the observation group was significantly higher than that in the control group (P<0.05). However, the total number of adverse reactions was similar in both groups (P>0.05 ). Conclusions Magnesium valproate combined with risleridone has an excellent clinical efficacy in the treatment of schizophrenia with negative symptoms. Therefore it is worth popularizing and applying on clinic.
【key words 】Magnesium valproate; Risperidone; Schizophrenia; negative symptoms
【中图分类号】R749.3 【文献标识码】B【文章编号】1004-4949(2015)02-0030-01
精神分裂在精神病中具有较高的患病率,但是其发病原因尚未明确,而多数学者则认为此病的发病原因为遗传因素[1]。大量的国内外研究表明,利培酮用于精神分裂的治疗中具有良好的效果,且此种药物并没有相应的毒副作用,而丙戊酸镁具有抗癫痫作用。此研究对我院选取的66例精神分裂阴性症状患者的临床资料进行分析,现报道如下:
1 资料与方法
1.1 一般资料
选取我院2013年3月至2015年1月期间收治的66例精神分裂阴性症状患者,所有患者均符合中国精神障碍分类的诊断标准。按照抽签法将其分为观察组以及对照组,每组患者为33例,在对照组患者中,男性为21例,女性为12例,患者年龄均在26-47岁之间,平均年龄为(33.5±3.6)岁;在观察组患者中,男性为19例,女性为14例,患者年龄均在24-45岁之间,平均年龄为(31.8±2.4)岁,两组患者并无伴发性疾病,比较两组患者的一般资料,无显著差异,不具有统计学意义(P>0.05),具有可比性。……p>
