赵艳华　李晓梅

【摘 要】目的：观察高压氧联合体外反搏治疗围绝经期失眠症的疗效。方法：选择符合诊断标准的患者共74例，随机分为对照组38例，给予西药常规治疗；治疗组36例，在西药对照组常规治疗的基础上，加用高压氧联合体外反搏治疗。在治疗结束时，通过睡眠改善情况及血清促卵泡激素（FSH）、促黄体生成激素（LH）、雌二醇（E2）含量改善情况对两组患者进行疗效评定。结果：治疗组与对照组比较，治疗组睡眠改善情况与FSH、LH、E2含量改善有效率为94.44%、83.33%，对照组分别为73.68%、52.63%，经统计学处理，P<0.05。结论：高压氧联合体外反搏治疗配合西药综合治疗围绝经期失眠症疗效显著。

【关键词】高压氧；體外反搏；围绝经期；失眠

Effect of hyperbaric oxygen combined with external counterpulsation treatment of perimenopausal insomnia

Zhao Yanhua and Li Xiaomei

Ziyang People's Hospital， Ziyang， Sichuan 641301

[Abstract]Objective： To observe the curative effect of hyperbaric oxygen combined with external counterpulsation for the treatment of perimenopausal insomnia. Methods： According to the diagnosis standard， a total of 74 patients were randomly selected and randomly divided into a control group （38 patients） and a treatment group （36 patients）. The control group was given conventional medicine treatment and the treatment group， on the basis of conventional medicine treatment， was treated with hyperbaric oxygen combined external counterpulsation. At the end of the treatment， curative effect evaluation was made through the improvement of sleep and the improvement of serum follicle stimulating hormone （FSH）， luteinizing hormone （LH）， and estradiol （E2） levels. Results： The effective rate of sleep improvement and FSH， LH， E2 levels improvement was 94.44% and 83.33% in the treatment group and that of the control group was 73.68% and 52.63%. Statistic processing showed that P<0.05. Conclusion： The comprehensive treatment of hyperbaric oxygen combined with external counterpulsation therapy together with the medicine for perimenopausal insomnia has a remarkable curative effect.

[key words]Hyperbaric oxygen； External counterpulsation； Perimenopausal； Insomnia

围绝经期失眠症是由于年龄的增长，以卵巢功能的退行性改变为中心环节，进而出现下丘脑、垂体功能等退化而影响到全身各系统而出现的以失眠为突出表现的临床综合症候群[1]，是困扰围绝经期妇女的一种常见病、多发病。围绝经期是每个妇女生命过程中必然的生理过程，国外流行病学资料表明，33%～51%的围绝经期妇女存在睡眠障碍[2]，直接影响到患者正常的生活和工作质量。我们应用高压氧（HBO）联合体外反搏（ECP）治疗围绝经期失眠症取得较好的临床疗效，现报道如下。

1 资料与方法

1.1 一般资料

2010年11月至2014年8月在本院门诊及住院治疗的围绝经期失眠症患者，结合《妇产科学》[3]中“围绝经期综合症”及失眠症诊断标准[4]制定本诊断标准：①年龄在45～55周岁；有月经紊乱、潮热汗出、抑郁焦虑、心慌、皮肤蚁行感等自我感觉异常症状；内分泌测定：促卵泡激素（FSH）、促黄体生成激素（LH）升高，雌二醇（E2）降低（低于卵泡早期水平）。……