陈春毅

[摘要] 目的 研究黄芪注射液联合阿魏酸钠治疗原发性肾病综合征的效果，探讨其临床适用性。 方法 选取2013年4月～2014年10月在本院就诊的78例原发性肾病综合征患者，将其随机分为对照组（39例）和实验组（39例）。对照组采用常规治疗及抗凝、改善脂代谢等对症治疗，实验组在对照组基础上给予黄芪注射液联合阿魏酸钠注射液静脉点滴，4周为1个疗程。比较两组治疗后的24 h尿蛋白、血清白蛋白、三酰甘油、总胆固醇及低密度脂蛋白含量。 结果 治疗后，实验组的血清白蛋白含量明显上升，尿蛋白、三酰甘油、总胆固醇及低密度脂蛋白含量明显下降，对照组变化不明显，差异有统计学意义（P<0.05），实验组的总有效率为97.44%，明显高于对照组的69.23%，差异有统计学意义（P<0.05）。 结论 黄芪注射液联合阿魏酸钠治疗原发性肾病综合征的效果显著，能明显改善患者的肾功能，值得临床推广应用。

[关键词] 黄芪；阿魏酸钠；原发性肾病综合征

[中图分类号] R692.9 [文献标识码] A [文章编号] 1674-4721（2015）07（b）-0109-03

[Abstract] Objective To study the effect of Huangqi injection combined with sodium ferulate in the treatment of primary nephrotic syndrome in order to explore its clinical applicability. Methods From April 2013 to October 2014，78 patients with primary nephrotic syndrome visited our hospital for treatment were selected and evenly divided into control group and experimental group in random.In control group，conventional treatment combined with symptomatic therapies like anticoagulation and improvement of lipid metabolism and so on was adopted.In experimental group，on the basis of control group，Huangqi injection combined with sodium ferulate injection for intravenous drip was added.One course of treatment lasted 4 weeks.24 h urine protein，serum albumin，triglycerides，total cholesterol and low density lipoprotein level after treatment was compared respectively between two groups. Results After therapy，the content of serum albumin was greatly increased，while the content of urine protein，triglycerides，total cholesterol and low density lipoprotein level was remarkably decreased in experimental group，while change in control group were not obvious，and there was a statistical difference （P<0.05）.The total effective rate in experimental group （97.44%） was obviously higher than that in control group （69.23%），and there was a statistical difference （P<0.05）. Conclusion Huangqi injection combined with sodium ferulate obtains a remarkable effect on treating primary nephrotic syndrome and can significantly improve renal function of patients.It is worthy of clinical promotion and application.

[Key words] Huangqi；Sodium ferulate；Primary nephrotic syndrome

原发性肾病综合征是肾内科的常见疾病之一，以低蛋白血症、大量蛋白尿、高脂血症、水肿为主要临床特征[1]，是由多种原因导致的肾小球基底膜电荷屏障、机械屏障受损而导致通透性增加，血浆内蛋白质从尿中大量丢失[2]，肝脏增加代偿性合成蛋白质时也会明显增加脂蛋白、胆固醇的合成，从而导致高脂血症，引发一系列生理、病理变化[3]。临床上采用的常规治疗大多以激素为主，加降脂、抗凝等，但效果并不显著，且伴随较多不良反应[4]。近年来，有研究表明，黄芪及阿魏酸钠对原发性肾病综合征的治疗有较为显著的效果[5]，本文研究了黄芪注射液联合阿魏酸钠治疗原发性肾病综合征的效果，现报告如下。……