针对小儿心脏手术促红细胞生成素治疗和术前自体献血的临床研究
2015-08-29陈磊等
陈磊等

[摘要] 目的 对小儿心脏手术促红细胞生成素(EPO)治疗和术前自体献血展开临床研究,为日后的临床治疗提供参考。 方法 选择2010年3月—2012年1月前来该院进行小儿心脏手术患儿50例为研究对象,随机分为观察组及对照组,每组患者25例。观察组患者于术前3 d连续应用促红细胞生成素治疗,并且按照3次/周的频率进行皮下注射100 U/kg。患儿需口服硫酸亚铁60 mg/d,采2次血做手术备用。对照组患儿按照常规备血。对比两组患儿的红细胞(RBC)、血红蛋白(Hb)、红细胞压积(Hct)、白细胞(WBC)、血小板(Plt)状况。 结果 经过治疗后,观察组患儿的情况明显优于对照组。观察组患儿的术后RBC为(4.01±1.86),对照组为(3.73±1.22);观察组术后Hb为(114.11±1.12),对照组为(91.23±1.72);观察组术后Hct为(36.51±1.82),对照组为(29.86±1.43)。 结论 小儿心脏手术难度较高,通过应用促红细胞生成素治疗以及术前自体献血,可提高手术的成功率,并且对患儿的日后康复和成长都具有较大的积极意义,日后可在临床治疗中推广应用。
[关键词] 小儿;心脏手术;促红细胞生成素;自体献血
[中图分类号] R726.1 [文献标识码] A [文章编号] 1674-0742(2015)02(b)-0102-03
Clinical studies for pediatric cardiac surgery erythropoietin hormone treatment and surgery before generating autologous blood donation
CHEN Lei ZHAO Yongcheng WAN Zhikun ZHA Guangyan
Mudanjiang Cardiovascular Disease Hospital-Cardiac Surgery, 157000 China
[Abstract] Objective The pediatric cardiac surgery erythropoietin (EPO) therapy and autologous blood donation launched preoperative clinical studies, provide a reference for future clinical therapy. Methods March 2010 - 2012 January to come to our hospital for pediatric cardiac surgery in children with 50 cases for the study were randomly divided into two groups and the control group, 25 patients in each group. Observation of patients in three days of continuous use before surgery erythropoietin treatment, and subcutaneous injection 100U / kg in accordance with the frequency of three times a week. Children need oral ferrous sulfate 60mg / d, taken twice a spare blood surgery. Children in the control group of blood in accordance with conventional equipment. Comparing two groups of children erythrocytes (RBC), hemoglobin (Hb), hematocrit (Hct), white blood cell (WBC), platelets (Plt) status. Results After treatment, the situation of children in the study group than the control group. RBC group was observed in children is (4.01±1.86), the control group was (3.73±1.22); observed postoperative Hb was (114.11±1.12), the control group was (91.23±1.72); observed postoperative Hct was (36.51±1.82), control group (29.86±1.43). Conclusion The higher the difficulty of pediatric heart surgery, through the application of erythropoietin therapy and preoperative autologous blood donation can improve the success rate of surgery, and rehabilitation of children in the future and growth have a greater positive significance in future clinical treatment application.
[Key words] Children; Cardiac surgery; Erythropoietin; Autologous blood donatioendprint
近年来,我国在血液回收技术方面取得了较大的进步,但在儿童心脏手术当中却不那么理想,很多患儿都存在缺铁性贫血,反复采血还可能导致患儿的贫血加重。促红细胞生成素联合术前自体献血在理论上是行得通的[1-3],但由于小儿心脏手术的限制性条件较多,并且血液输送会直接影响患儿的身体健康以及生命安全,仍然要谨慎进行。该研究主要对2010年3月—2012年1月该院收治的患儿进行小儿心脏手术促红细胞生成素治疗和术前自体献血的临床展开研究,现报道如下。……
