李静　贺金娥

[摘要] 目的 探析谷氨酰胺结合低渗口服补液盐治疗小儿腹泻的临床效果。 方法 选择2013年1月～2014年1月延安市第二人民医院儿科收治的100例腹泻患儿作为研究对象，按照随机分配的原则将其分成对照组和观察组，每组各50例。两组患者均给予抗感染治疗的同时采取维持肠道菌种平衡的措施。对照组单纯采用低渗口服补液盐进行治疗，观察组在此基础上使用复方谷氨酰胺肠溶胶囊进行联合治疗。观察患儿的症状改善情况并比较两组的治疗效果。 结果 观察组患儿腹泻缓解所用时间[（1.32±0.60）d]少于对照组[（5.85±2.04）d]，腹泻次数明显少于对照组，差异均有统计学意义（P < 0.05）。观察组治疗总有效率为94%，明显高于对照组的84%，差异有统计学意义（P < 0.05）。 结论 谷氨酰胺结合低渗口服补液盐治疗小儿腹泻可有效患儿的腹泻症状，缩短患儿恢复所用时间，不良反应少，通过改善患儿肠黏膜功能来治疗小儿腹泻，安全性高，效果显著，值得临床推广。

[关键词] 谷氨酰；肠黏膜；屏障；消化

[中图分类号] R969.2 [文献标识码] A [文章编号] 1673-7210（2015）05（c）-0104-03

[Abstract] Objective To analyze clinical curative effect of glutamine combined with low permeability of oral rehydration salts （ORS） in the treatment of infantile diarrhea. Methods 100 cases of children with diarrhea from January 2013 to January 2014 treated in the Second People's Hospital of Yan'an City were selected as the research objects， and in accordance with the method of random distribution， they were divided into control group and observation group， with 50 cases in each group. Children of two groups were given anti-infection therapy and measures of maintain balance of intestinal bacteria. Control group was just given the treatment of low permeability of ORS， observation group was given compound Glutamine enteric capsules on the basis of ORS. Symptoms of children were observed and curative effect of two groups were compared. Results Diarrhea ease use time of children in the observation group [（1.32±0.60）d] was less than that of the control group [（5.85±2.04）d]， and diarrhea frequency was less than that of the control group， the differences were statistically significant （P < 0.05）； the total effective rate of the observation group was 94%， that was significant higher than that of the control group （84%）， the difference was statistically significant P < 0.05）. Conclusion Glutamine combined with low permeability of ORS can effectively diarrhea symptoms of children with infantile diarrhea， shorten the recovery time， less adverse reactions， to solve the problem of diarrhea by improving the function of intestinal mucosa， is high safety， effective and worthy of clinical application.

[Key words] Glutamine； Intestinal mucosa；Barrier；Digestion

多种病原感染及多种病因是引起小儿腹泻的原因，2岁以下的婴儿较为多见，特别是6～11个月的婴儿尤为高发。每年6～9月及10月至次年1月是小儿腹泻发生的高峰期[1]。细菌感染引起的小儿腹泻是夏季腹泻，患儿表现为黏液便，并且大便具有腥臭味；与小儿夏季腹泻比较，小儿秋季腹泻多由轮状病毒感染引起，大便多为稀水样或稀糊状，而且无腥臭味。小儿腹泻是一种消化道综合征，发病原因比较多样，大便形状改变以及次数增多为主要特点，是导致小儿发育不良的重要原因。1971年，联合国际儿童基金会与世界卫生组织均推荐使用口服补液盐（oral rehydration salts，ORS）来治疗小儿腹泻[2-3]，效果较好，但依然存在着无法缩短病程以及减少腹泻次数的缺点。……