孙超　李志军

[摘要] 干燥综合征（Sjogrens syndrome，SS）为一种主要侵犯外分泌腺体的自身免疫病，同时也是一种慢性炎症性疾病。临床上标志性特点为外分泌腺和上皮细胞的淋巴细胞性浸润造成的典型眼干和口干症状，以及由外分泌腺功能障碍引起的干燥性角结膜炎、口腔干燥症等其他一系列表现。SS好发于女性并给患者生活带来极大的不便。尽管其发病原因并不清楚，目前的研究认为SS的发生受到免疫、遗传、细菌和病毒感染等因素的影响。目前，该病的治疗主要是缓解干燥症状或控制疾病发展速度，临床上尚无有效治疗药物。近年来不断有报道发现SS患者体内的Toll样受体4（toll-like receptor 4，TLR4）表达较健康人群明显增高，关于脂多糖（Lipopolysaccharides，LPS）介导的TLR4信号转导通路在SS中的作用正受到越来越多的关注。本文就TLR4受体在SS中的作用进展进行综述。

[关键词] Toll样受体4；干燥综合征；自身免疫性疾病

[中图分类号] R589 [文献标识码] A [文章编号] 1673-9701（2015）08-0153-04

[Abstract] Sjogren's syndrome（SS） is a chronic autoimmune disease affecting primarily the exocrine glands. In clinic， SS is characterized by infiltration of lymphocytes into glandular tissues， typically the salivary and lacrimal glands， leading to keratoconjunctivitis sicca（dry eye） andxerostomia（dry mouth）. Morever， SS is associated with a high prevalence in women and brings great harm to the patient. Although the cause of SS is unknown， it is believed to be under the influence of immune， genetic， bacterial infections，viral infections，and several other factors. Currently， treatments for SS consist of therapies aimed at relieving specific symptoms， such as dry eyes or dry mouth， or targeted at trying to control the underlying disease process. There is no effective drug treatments. Recently， several studies have found that the blood serum level of toll-like receptor 4（TLR4） in patients with SS was significantly higher than healthy control group. The role of LPS-induced TLR4 signal transduction pathway played in SS has attracted more and more attention. In this paper， we reviewed the role of TLR4 in SS.

[Key words] Toll-like receptor 4；Sjogrens syndrome；Autoimmune disease

干燥综合征（Sjogrens syndrome，SS）为一种主要侵犯外分泌腺体的自身免疫病，同时也是一种慢性炎症性疾病。临床上标志性特点是由于外分泌腺和上皮细胞的淋巴细胞性浸润造成的典型眼干和口干症状，以及由外分泌腺功能障碍引起的干燥性角结膜炎、口腔干燥症等其他一系列表现[1-4]。该病可分为原发性干燥综合征（pSS）和继发性干燥综合征（sSS），其中pSS是指SS在患者无潜在自身免疫病的背景下单独发生，而sSS是指与患者体内潜在的其他自身免疫性疾病同时发生[2]。流行病学研究表明SS为全球性疾病且发病率高，约为0.2%～0.77%[4]。……