荣春兰

[摘要] 目的 探讨心可舒联合乙胺碘呋酮治疗冠心病快速心房纤颤的临床疗效。 方法 病例选自我院2011年12月～2013年12月收治的冠心病快速心房纤颤患者共90例，分为两组，其中对照组（n=45）单纯给予乙胺碘呋酮治疗，观察组（n=45）采取心可舒联合乙胺碘呋酮治疗，观察并比较两组临床治疗效果及不良反应发生情况。 结果 观察组总有效率为91.11%，显著高于对照组的77.78%，两组比较差异有统计学意义（P<0.05）；观察组不良反应发生率为6.66%，显著低于对照组的26.67%，两组比较差异有统计学意义（P<0.05）。 结论 心可舒联合乙胺碘呋酮治疗冠心病快速心房纤颤疗效确切，可有效控制心室率，改善临床症状，且不良反应发生率低，安全性好，具有较好的临床应用价值。

[关键词] 心可舒；乙胺碘呋酮；心房纤颤

[中图分类号] R541.4 [文献标识码] B [文章编号] 2095-0616（2014）17-59-03

[Abstract] Objective To explore the clinical effect of combined Xinkeshu tablets and amiodarone in patients with coronary heart disease of fast atrial fibrillation. Methods 90 cases with coronary heart disease of fast atrial fibrillation treated in our hospital from December 2011 to December 2013 were selected，that were divided into two group， patients in control group（n=45） received amiodarone treatment， observation group（n=45） received Xinkeshu and amiodarone treatment， clinical effect and adverse events were compared before and after being treated. Results The effective treatment rate of observation group was 91.11%， The date was significantly higher than the 77.78% of control group， differences were statistically significant （P<0.05），The adverse reactions rate of observation group was 6.66%， the date was significantly lower than 26.67% of control group， Differences were statistically significant （P<0.05）. Conclusion The combined treatment of Xinkeshu tablets and amiodarone could obtain better curative effect in the treatment of coronary heart disease of fast atrial fibrillation， and can effectively improve the clinical symptoms and clinical treatment outcomes， and it has a low incidence of adverse reactions and drug safety，and is worth of clinical application and promotion.

[Key words] Xinkeshu tablets； Amiodarone； Atrial fibrillation

心房纤颤（简称房颤）是临床上较为常见且危害严重的一种心律失常，指心房的快速、不规则的颤动，呈阵发性或持续性发作，可导致患者运动耐量降低，增加基础心脏病的病死率等，其发病率较高且随老龄化的发展而呈逐年增加的趋势，严重威胁患者的生命安全[1-3]。因此，临床治疗应控制其心室率，使其尽快转复为窦性心律，以缓解患者临床症状，保护其心功能[4]。目前临床使用的治疗药物繁多，但效果一般且副反应多，本研究采取心可舒联合乙胺碘呋酮治疗冠心病快速心房纤颤取得了显著疗效，现报道如下。

1 资料与方法

1.1 一般资料

研究病例均选自我院2011年12月～2013年12月收治的冠心病快速心房纤颤患者共90例，均符合WHO关于冠心病心房纤颤的诊断标准，其中男51例，女39例，年龄47～82岁，平均（60.5±3.6）岁。排除高血压、低钾血症或具有电解质紊乱者；既往有房颤史者；甲状腺功能亢进者；肝、肾等重要器官功能损害者；……