张林山+杨燕春+胡军+杨长华+万景军

doi：10.3969/j.issn.1007-614x.2014.14.14

摘 要 目的：研究奥美拉唑与生长抑素联合治疗食管静脉曲张破裂出血的临床有效性与安全性。方法：将进行治疗的142例食管静脉曲张破裂出血患者随机分为试验组和对照组，试验组给予奥美拉唑与生长抑素进行联合治疗，对照组仅给予生长抑素治疗，比较两组患者的治疗效果。结果：试验组71例患者中，显效38例（53.5%），有效25例（35.2%），无效8例（11.2%）；对照组71例患者中，显效23例（32.3%），有效31例（43.6%），无效17例（23.9%），试验组的治疗效果优于对照组（P<0.05）。结论：生长抑素联合奥美拉唑在治疗食管静脉曲张破裂出血中能够显著控制出血症状，提高用药安全性，值得临床推广应用。

关键词 生长抑素 奥美拉唑 疗效评价

Comprehensive evaluation of the clinical efficacy and safety of omeprazole combined with somatostatin in the treatment of esophagus varicosity burst hemorrhage

Zhang Linshan，Yang Yanchun，Hu Jun ，Yang Changhua，Wan Jingjun

The internal medicine of the people's hospital in Sansui County，Qiandongnan State，Guizhou Province，556500

Abstract Objective：To study the clinical efficacy and safety of omeprazole combined with somatostatin in the treatment of esophagus varicosity burst hemorrhage.Methods：142 cases of patients with esophagus varicosity burst hemorrhage for treatment were randomly divided into the experimental group and the control group.The experimental group were given omeprazole combined with somatostatin treatment，while the control group were only given somatostatin treatment.Compare the treatment effect of patients between two groups.Results：In the 71 cases of patients in the experimental group，markedly effective was 38 cases（53.5%），effective was 25 cases（35.2%），invalid was 8 cases（11.2%）.In the 71 cases of patients in the control group，markedly effective was 23 cases（32.3%），effective was 31 cases（43.6%），invalid was 17 cases（23.9%）.The treatment effect of the experimental group was better than that of the control group（P<0.05）.Conclusion：Somatostatin combined with omeprazole in the treatment of esophagus varicosity burst hemorrhage can significantly control the bleeding symptoms，enhance the medication security，so it is worthy of clinical application.

Key words Somatostatin；Omeprazole；Therapeutic evaluation

肝硬化门脉高压极其容易导致食管静脉曲张破裂出血，该病发病隐匿且突然，致死率高，是肝硬化患者的重要致死原因，也是临床研究和治疗的难点。目前临床上对于该病的治疗主要从抑制出血和治疗原发病两个方面着手，必要时进行辅助输血。奥美拉唑是强力的质子抑制剂，对于促进创口血液凝结、减缓胃酸的分泌速度有重要作用。生长抑素由于代谢周期短，浓度提高速度快，能够有效降低消化道静脉的血压和血液流速，促进血栓形成，加速止血效果[1]。本次试验拟联合两者治疗食管静脉曲张破裂出血，现报告如下。

资料与方法

研究对象：142例食管静脉曲张破裂患者参与治疗研究，平均年龄（50.15±10.63）岁，男女比例87：55。患者皆因呕血或便血症状送医，经病理检验、超声和CT检测确诊为食管静脉曲张破裂出血。……