江小梅++++++杨志锋++++++彭杰文++++++萧剑军

[摘要] 目的 探讨奥沙利铂联合腹腔热灌注治疗胃癌的临床应用价值，为今后的临床工作提供借鉴。 方法 选取2009年1月～2013年12月本院收治的80例胃癌患者，将其随机分为治疗组和对照组，每组各40例，两组患者均采用亚叶酸钙、奥沙利铂、氟尿嘧啶进行化疗，治疗组在此基础上增加腹腔热灌注化疗，观察两组患者的临床疗效。 结果 经过2个周期的治疗，治疗组与对照组的总有效率分别为72.50%和62.50%，治疗组显著高于对照组（P<0.05）。其中治疗组完全缓解（CR）13例，CR率为32.50%。对照组CR 10例，CR率为25.00%，实验组显著高于对照组（P<0.05）。 结论 奥沙利铂联合腹腔热灌注化疗治疗胃癌的临床效果较单用化疗药物显著。

[关键词] 奥沙利铂；腹腔热灌注；进展期胃癌

[中图分类号] R735.2[文献标识码] A[文章编号] 1674-4721（2014）06（b）-0071-03

Effect observation of oxaliplatin combining with hyperthermic peritoneal perfusion chemotherapy on treating advanced gastric carcinoma

JIANG Xiao-mei YANG Zhi-feng PENG Jie-wen XIAO Jian-jun

People′s Hospital of Zhongshan City in Guangdong Province,Zhongshan 528400,China

[Abstract] Objective To explore the clinical application value of oxaliplatin combining with hyperthermic peritoneal perfusion chemotherapy on treating gastric carcinoma in order to provide reference for clinical work in future. Methods Eighty patients with gastric carcinoma admitted into our hospital from January 2009 to December 2013 were randomly divided into treatment group and control group.Calcium folinate,oxaliplatin,and fluorouracil were provided for the treatment in both groups.On this basis,hyperthermic peritoneal perfusion chemotherapy was added.The clinical effect in the two groups was observed. Results After two-week treatment,the total effective rate in the treatment group and control group was 72.50% and 62.50% respectively.The index in the treatment group was remarkably higher than that in the control group with a statistical difference (P<0.05).The number of complete remission in the treatment group was 13 cases,accounting for 32.50%.In the control group were 10 cases in CR,the complete remission rate was 25.00%.After comparison,the former was higher,which displayed a statistical difference (P<0.05). Conclusion The clinical effect on treating patient with gastric carcinoma is more remarkable by oxaliplatin combining with hyperthermic peritoneal perfusion chemotherapy than that by chemotherapeutic drug alone.

[Key words] Oxaliplatin;Hyperthermic peritoneal perfusion chemotherapy;Advanced gastric carcinoma

我国是胃癌发病大国，发病率、死亡率均排在恶性肿瘤的首位。胃癌早期症状不太明显，大多数胃癌患者初次就诊时已为晚期，临床常采用姑息性化疗，可以有效延长生存期，但是疗效并不理想[1]。近几年来有相关文献报道，腹腔热灌注化疗技术（continuous hyperthermic peritoneal perfusion chemotherapy，CHPPC）较多应用在进展期胃癌患者的术后辅助治疗中，并发挥重要作用[2]。本研究采用奥沙利铂联合腹腔热灌注治疗40例进展期胃癌患者，与对照组相比，临床效果较好。

1 资料与方法

1.1 一般资料

选取本院2009年1月～2013年12月收治的80例胃癌患者为研究对象，根据治疗方法将其随机分为治疗组和对照组，每组各40例。其中治疗组男24例.女16例；病程6个月～2年；年龄44～64岁，平均（51.49±12.51）岁；初治25例，复治15例。对照组男22例，女18例，病程6个月～2年；年龄42～66岁，平均（51.43±13.24）岁；初治24例，复治16例。两组患者的性别、病程、年龄等一般资料，差异无统计学意义（P>0.05），具有可比性。……