李承果+吴庆能+凌钦杰+钟燕容+董兰菊+钟赛琼

[摘要] 目的 研究生肌膏联合封闭负压引流术治疗难愈创口的临床效果。 方法 选取本院外科难治愈创口患者60例，随机分为治疗组和对照组各30例。对照组患者单独应用封闭负压引流术对创口进行处理，治疗组患者在对照组治疗方法的基础上联合应用生肌膏治疗。比较两组的临床疗效。 结果 治疗组总有效率为93.4%，显著高于对照组的73.3%，差异有统计学意义（P＜0.05）。治疗组平均恢复时间、创面渗液干净时间、肉芽组织生长时间、上皮组织生长时间显著短于对照组（P＜0.05）。 结论 生肌膏联合封闭负压引流术治疗难愈创口的效果显著，能够减少治疗时间，降低治疗费用。

[关键词] 负压吸引；生肌膏；难愈创口

[中图分类号] R641[文献标识码] A[文章编号] 1674-4721（2014）04（c）-0090-03

Clinical effect of gynogenic ointment combined with vacuum sealing drainage in the treatment of refractory wound

LI Cheng-guo WU Qing-neng LING Qin-jie ZHONG Yan-rong DONG Lan-ju ZHONG Sai-qiong

The Fourth Surgical Department of the Fifth Affiliated Hospital to Southern Medical University (the Central Hospital of Conghua City),Conghua 510900,China

[Abstract] Objective To discuss the clinical effect of gynogenic ointment combined with vacuum sealing drainage in the treatment of refractory wound.Methods 60 cases of wound patients in surgical department of our hospital were divided into treatment group and control group randomly.30 patients in control group were given with vacuum sealing drainage on wound treatment singly.30 patients in treatment group were given with the treatment of gynogenic ointment based on the control group.The clinical efficacy was observed betweent two groups.Results The total effective rate of treatment group was 93.4%,was significantly higher than 73.3% of the control group (P<0.05).The average recovery time,clean the wound exudate time,granulation tissue growth time,the growth of epithelial tissue in the treatment group was significantly shorter than that of the control group respectively (P<0.05).Conclusion Application of vacuum sealing drainage combined with gynogenic ointment on wound healing in patients is remarkable with the advantage to reduce the treatment time and cost.

[Key words] Vacuum sealing drainage;Gynogenic ointment;Refractory wound

难愈创口主要是指由于严重创伤造成皮肤及软组织大面积缺损或慢性创口，具有创面面积大、深度深、慢性伤口细胞外机制重构严重、再上皮化受抑制以及长时间炎症反应等特征。一般多见于严重软组织挫伤、皮肤撕脱、大面积血肿或积液、手术切口感染、糖尿病足等。随着我国交通及工业的逐渐发展及人口老龄化速度的加快，近年来难愈创面人数显著增加[1]。临床治疗步骤繁琐、治疗时间长，患者除忍受病痛外还需承受心理及精神压力，对疾病治疗及预后产生了较大影响。将目前临床负压封闭吸引术进行改良型探索并结合生肌膏共同治疗可有效减轻患者的痛苦，加速创面愈合速度，缩短病程，显著改善患者的生活质量，提高疾病治疗效率。……