/Lian Zhenqiang(连臻强，Breast Dis Center，Guangdong Women Children Hosp，Guangzhou Med Col，Materal Child Health Hosp Guangdong，Guangzhou 510010)…∥Chin J Surg.-2011，49(10).-918～922

ObjectiveTo evaluate the clinical application of high-frequency ultrasound-guided vacuum-assisted biopsy for breast microcalcifications.MethodsSixty-six patients with 70 lesions of microcalcifications detected at mammography underwenthigh-frequency ultrasoundguided vacuum-assisted biopsy from July 2009 to October 2010.All patients were female，aged 24 to 61 years(median age 40 years).Among 70 lesions of microcalcifications，unilateral lesions were 62 cases and bilateral lesions were 4 cases.The clinical factors that affected the success of biopsy were investigated by x2test and Logistic regres-sion analysis.ResultsAmong 70 lesions of microcalcifications，the successful rate of biopsy was 72.9%(51/70).The biopsy successful rate of microcalcifications without and with masses were 65.2% (30/46)and 87.5%(21/34)respectively(x2=3.960，P=0.047).The biopsy successful rate of microcalcifications of maximal diameter more than 5 mm was higher than that of maximal diameter less than 5 mm(88.9%vs.55.9%，x2=9.633，P=0.002).The Logistic regression analysis showed that the types and maximal diameter of microcalcifications were the main factors that affected the success of biopsy.ConclusionThe clinical application of highfrequency ultrasound-guided vacuum-assisted biopsy was an effective option for the diagnosis of breast microcalcifications，especially for the type of microcalcifications with masses and the maximal diameter more than 5 mm.13 refs，2 figs，2 tabs.