EDITORIAL

1. Highlighted multi-modifications of enzymes: a novel succinylation mediated by histone acetyltransferase 1 in tumors
2. A CRISPR-Cas9 screen shows the combination efficacy of lenvatinib plus epidermal growth factor receptor inhibitors for treatment of liver cancer
3. The emerging role of long noncoding RNA RMRP in cancer development and targeted therapy

REVIEW

1. Tumorigenic bacteria in colorectal cancer: mechanisms and treatments
2. Cancer metabolism and dietary interventions
3. The advance of adjuvant treatment for triple-negative breast cancer
4. Updates in endocrine therapy for metastatic breast cancer

ORIGINAL ARTICLE

1. Efficacy of rigosertib,a small molecular RAS signaling disrupter for the treatment of KRAS-mutant colorectal cancer
2. Systematic screening reveals synergistic interactions that overcome MAPK inhibitor resistance in cancer cells
3. Association between 15 known or potential breast cancer susceptibility genes and breast cancer risks in Chinese women

1. Erratum to A truncated protein product of the germline variant of the DUOX2 gene leads to adenomatous polyposis